Melbourne BioViz

Category Archive: Videos

Bordetella pertussis and Whooping Cough

This animation describes the process of infection of the airways by Bordetella pertussis, a bacterium which causes whooping cough. It specifically details how the bacterium damages ciliated airway cells, impairing normal respiratory function,

Autonomic control of the iris

Thanks to the function of the autonomic nervous system (ANS) your body is incredibly good at completing important tasks without your conscious input. In this video, the pathways controlling the tone of muscles in the iris (and therefore amount of light that enters the eye) are investigated. There are two[…]

Respiratory Systems

A short video indicating the location of some of the major components of the respiratory system in humans. Using different materials and fading objects in and out, we can highlight individual objects to assist students in identifying structures that would be otherwise obscured when using a solid material. Text labels[…]

Prion Proteins

Prion proteins are found on the surface of many different cells, but their role is not entirely clear. Interestingly, mis-folded forms of the protein have the ability to become infectious and corrupt other normal folded prion proteins causing disease such as Creutzfeldt–Jakob disease and bovine spongiform encephalopathy (better known as[…]

Cytotoxic T cell function – Imaging CoE launch

This animation was commissioned for the launch of the Centre for Advanced Molecular Imaging to highlight key themes of the research involved. In this scene, we follow a cytotoxic T cell (or killer T cell) as it patrols the body for potentially harmful pathogens.  Using specialised T cell receptors (TCR)[…]

Part 2: Insulin Receptor and Type 2 Diabetes

This animation describes the role of the insulin receptor in type 2 diabetes. It focuses on the very recent discovery of how the hormone insulin actually binds to the receptor on the surface of cells, as determined by Prof Mike Lawrence’s lab at the Walter and Eliza Hall Institute of[…]

Inflammation and Type 2 Diabetes

This animation describes recent discoveries about the process of inflammation as it relates to type 2 diabetes. It focuses on the role of the newly-discovered ‘inflammasome’, which is being studied by researchers at the Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. The inflammasome is an amazingly complex[…]

Pore Forming Toxin

Certain bacteria such as Clostridium perfringens have a particularly nasty trick. They produce a potent pore-forming toxin which assembles on cell membranes as a doughnut-shaped complex, before punching a hole and killing the cell. This animation starts from an electron microscopy image of the pore complexes formed on membranes before[…]

Poliovirus Supercomputer Simulations

This video shows the reconstruction and simulation of poliovirus using the BlueGene/Q supercomputer at the Victorian Life Sciences Computation Initiative. The poliovirus model is being used as a basis for understanding antiviral drugs, virus infection and helps us to learn how to model related viruses such as Enterovirus 71 (excerpt[…]